OK, well again I'm not an engineer but I do know it isn't normal for those messages to repeat that many times. Until someone smarter comes along, my read of it is that the OS X kernel is reporting that the USB controller got a signal to activate. And it's happening a lot, abnormally so. It's acting like a USB device is getting plugged in constantly, which is obviously not true. Growl is probably not causing this, it is just the messenger. The question is, what is kicking the USB controller?

If it was my machine, I would plug and unplug something from every USB port to try and reset them, in case there is a short circuit across a pin or something. I would also become suspicious of the drivers of my USB devices in case one wasn't working right.

Hope that gets you somewhere.

Thanks man... I got off the phone with Apple not too long ago. They are having their engineers look at my log and system info.

Follow Up?
 

I have a MBP 2.2 also and have noticed similar entries in my system.log and was wondering what the out come of your situation was. I took my computer into apple (the keyboard and mouse would randomly freeze up) and they replaced the keyboard and uppercase on the 19th on jan... an excerpt from my system.log is below. I think the wake events are normal, however I don't know for sure, the null and false returns are weird though and sometimes seemed to follow when my trackpad and mouse would malfunction.
Jan 19 15:37:22 localhost kernel[0]: USB caused wake event (EHCI)
Jan 19 15:37:22 localhost kernel[0]: USB caused wake event (EHCI)
Jan 19 11:27:49 localhost kernel[0]: USB caused wake event (EHCI)
Jan 19 11:27:49 localhost kernel[0]: USB caused wake event (EHCI)
Jan 19 11:27:49 localhost kernel[0]: Extension "com.apple.driver.AppleUSBTCKeyboard" has no kernel dependency.
Jan 19 11:27:49 localhost kernel[0]: Extension "com.apple.driver.AppleUSBTCKeyEventDriver" has no kernel dependency.
Jan 19 18:57:53 localhost kernel[0]: USB caused wake event (EHCI)
Jan 19 18:57:53 localhost kernel[0]: USB caused wake event (EHCI)
Jan 19 19:20:29 aaron-cantrells-computer kernel[0]: USBF: 1371.707 IOUSBCompositeDriver[0x3e27c00](IOUSBDevice) GetFullConfigDescriptor(0) returned NULL
Jan 19 19:28:36 aaron-cantrells-computer kernel[0]: USBF: 1858.994 IOUSBCompositeDriver[0x59afa00](IOUSBDevice) GetFullConfigDescriptor(0) returned NULL
Jan 19 19:28:36 aaron-cantrells-computer kernel[0]: USBF: 1859.157 AppleUSBTCKeyboard[0x484ac00]::start - super::start returned false!
Jan 19 19:28:36 aaron-cantrells-computer kernel[0]: USBF: 1859.157 AppleUSBTCKeyboard[0x484ac00]::start - aborting startup
Jan 19 19:28:36 aaron-cantrells-computer kernel[0]: USBF: 1859.160 IOUSBHIDDriver[0x404a100]::start - super::start returned false!
Jan 19 19:28:36 aaron-cantrells-computer kernel[0]: USBF: 1859.160 IOUSBHIDDriver[0x404a100]::start - aborting startup
Jan 19 19:28:36 aaron-cantrells-computer kernel[0]: USBF: 1859.163 IOUSBHIDDriver[0x402f400]::start - super::start returned false!
Jan 19 19:28:36 aaron-cantrells-computer kernel[0]: USBF: 1859.163 IOUSBHIDDriver[0x402f400]::start - aborting startup
Jan 19 19:28:36 aaron-cantrells-computer kernel[0]: USBF: 1859.184 IOUSBHIDDriver[0x5050500]::start - super::start returned false!
Jan 19 19:28:36 aaron-cantrells-computer kernel[0]: USBF: 1859.184 IOUSBHIDDriver[0x5050500]::start - aborting startup
Jan 19 19:28:36 aaron-cantrells-computer kernel[0]: USBF: 1859.187 IOUSBHIDDriver[0x402f200]::start - super::start returned false!
Jan 19 19:28:36 aaron-cantrells-computer kernel[0]: USBF: 1859.187 IOUSBHIDDriver[0x402f200]::start - aborting startup
Jan 19 19:28:36 aaron-cantrells-computer kernel[0]: USBF: 1859.205 AppleUSBTCKeyboard[0x484ac00]::start - super::start returned false!
Jan 19 19:28:36 aaron-cantrells-computer kernel[0]: USBF: 1859.205 AppleUSBTCKeyboard[0x484ac00]::start - aborting startup
Jan 19 19:28:36 aaron-cantrells-computer kernel[0]: USBF: 1859.208 IOUSBHIDDriver[0x5050500]::start - super::start returned false!
Jan 19 19:28:36 aaron-cantrells-computer kernel[0]: USBF: 1859.208 IOUSBHIDDriver[0x5050500]::start - aborting startup
Jan 19 20:30:42 localhost kernel[0]: USB caused wake event (EHCI)
Jan 19 20:30:42 localhost kernel[0]: USB caused wake event (EHCI)
Jan 19 20:39:15 aaron-cantrells-computer kernel[0]: IOUSBWorkLoop::closeGate - interrupt Thread being held offUSB caused wake event (EHCI)
Jan 19 20:42:53 aaron-cantrells-computer kernel[0]: IOUSBWorkLoop::closeGate - interrupt Thread being held offEnabling XMM register save/restore and SSE/SSE2 opcodes
Jan 23 10:15:48 localhost kernel[0]: USB caused wake event (EHCI)
Jan 23 10:15:48 localhost kernel[0]: USB caused wake event (EHCI)
Jan 23 12:24:19 localhost kernel[0]: USB caused wake event (EHCI)
Jan 23 12:24:19 localhost kernel[0]: USB caused wake event (EHCI)
Jan 23 12:28:11 aaron-cantrells-computer kernel[0]: IOUSBWorkLoop::closeGate - interrupt Thread being held offEnabling XMM register save/restore and SSE/SSE2 opcodes
Jan 23 12:30:31 localhost kernel[0]: USB caused wake event (EHCI)
Jan 23 12:30:31 localhost kernel[0]: USB caused wake event (EHCI)
Jan 23 12:51:48 aaron-cantrells-computer kernel[0]: IOUSBWorkLoop::closeGate - interrupt Thread being held offIOBluetoothHCIController::terminateWL .. done